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Our Aspiration

To imagine, inspire, and transform

Aprecia is a specialty pharmaceutical company that’s committed to transforming customers’ experience with highly prescribed high-dose medications. We imagine a world where oral medications are no longer challenging for patients to take or for caregivers to give. And we inspire each other every day to seek innovative solutions that address administration and adherence needs.

Built upon our proprietary three-dimensional printing (3DP) technology platform, we focus on opportunities where there is a need for medicines that are easy to take. Aprecia is the first and only company in the world utilizing this cutting-edge 3DP technology platform to develop and manufacture pharmaceutical products on a commercial scale. We believe our platform will generate multiple product-enhancing drug delivery technologies that can be used in a variety of therapeutic categories. Our first innovation that leverages 3DP is ZipDose® Technology, which will be utilized in multiple product candidates.

ZipDose® Technology is based on a simple premise: medicine should be simple for caregivers to administer and for patients to swallow.

The adherence challenge

Getting medicine into the body reliably and accurately can be a challenge. We see it as an opportunity.

Taking medications orally, in the formulations that are currently available, works well for many people most of the time. However, liquids, tablets, and capsules can pose administration and/or swallowing challenges for patients.1,2 Patient-related factors such as age, personal habits, and/or insufficient knowledge about medications/illnesses may contribute to swallowing difficulties and affect drug adherence. In particular, children, the elderly, and special patient groups (such as those who have certain genetic or developmental disorders, tumors, neurological issues, or suffered brain trauma) may be more prone to having difficulty taking medications orally.3,4

As with any medical issue, it's important that patients continue with therapy as prescribed by their healthcare providers.

Some patients may cope by crushing tablets or opening capsules, which presents an adherence challenge and can result in lost medical benefit and/or serious adverse effects.4 Liquids are sometimes a useful alternative. However, they may pose additional challenges, such as the need for precise measurement, the potential for spilling, taste issues, and refrigeration requirements.2,3,5

At Aprecia, we believe that helping to overcome these obstacles can translate into enhanced experiences with medications by addressing patient adherence and accuracy of dosing, to help minimize distress for both patients and caregivers.

The potential of ZipDose® Technology

Our ZipDose® Technology will help serve patients who need medicines that are easy to take and caregivers—including physicians and nurse practitioners—who want medicines that are easy to administer. Aprecia believes that through ZipDose® Technology, we can help address adherence challenges and enhance our customers’ overall experience with highly prescribed high-dose medications.

References: 1. OTC Company News. Hermes highlights need for better formats. http://www.hermes-pharma.com/fileadmin/data/download/Hermes_highlights_need_for_better_formats_OTCBulletin_250714.pdf. Published July 2014. Accessed November 19, 2014. 2. Smith MD, Spiller HA, Casavant MJ, et al. Out-of-Hospital Medication Errors Among Young Children in the United States, 2002–2012. Pediatrics. 2014;134(5):867–876. 3. National Institutes of Health, National Cancer Institute. Medicine & your child: a guide for parents on adherence and administration. http://pediatrics.cancer.gov/scientific_programs/psychosocial/docs/MedBooklet.pdf. Published March 2011. Accessed August 25, 2014. 4. Stegemann S, Gosch M, Breitkreutz J. Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy. Int J Pharm. 2012;430:197–206. 5. Centers for Disease Control and Prevention. Public Service Announcement: refrigerated drugs. http://emergency.cdc.gov/disasters/psa/refrigerateddrugs.asp. Published June 2012. Accessed July 22, 2015.