Adherence to medications regardless of medical condition is essential to successful treatment. The factors associated with nonadherence include patient-related factors, difficulties with communication between the patient and healthcare provider, disease-related factors, and medication-related factors such as pill burden and side-effects. It is likely that a multi-faceted approach tailored to each individual patient will be required to combat nonadherence in patients with epilepsy. As a part of this multi-faceted approach, the use of easy-to- swallow dosage forms, such as the ZipDose® formulation, may play an important part of future programs to help improve patient adherence to medications in epilepsy.